LGALS2

Description

The LGALS2 (galectin 2) is a protein-coding gene located on chromosome 22.

Galectin-2 is a protein encoded by the LGALS2 gene in humans. It is a soluble beta-galactoside binding lectin that forms a homodimer and can bind to Lymphotoxin alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, leading to an increased risk of myocardial infarction.

This protein binds beta-galactoside. Its physiological function is not yet known.

LGALS2 is also known as HL14.

Associated Diseases

• isolated agammaglobulinemia
• common variable immunodeficiency
• cancer
• immunodeficiency 72 with autoinflammation
• severe combined immunodeficiency due to CARD11 deficiency
• T-B+ severe combined immunodeficiency due to JAK3 deficiency
• severe combined immunodeficiency due to IKK2 deficiency
• combined immunodeficiency due to ZAP70 deficiency
• immunodeficiency 18
• autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
• severe combined immunodeficiency due to CTPS1 deficiency
• neutrophil immunodeficiency syndrome
• immunodeficiency 105
• immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias