LEUTX

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Description

The LEUTX (leucine twenty homeobox) is a protein-coding gene located on chromosome 19.

Isoform 1 of LEUTX, also known as Leucine-twenty homeobox, is a paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). It may act as a regulator of embryo genome activation (PubMed:27578796). LEUTX binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355). {ECO:0000269|PubMed:27578796, ECO:0000269|PubMed:30479355}

LEUTX is also known as -.

Associated Diseases

• Bartsocas-Papas syndrome 1
• myeloid leukemia
• facioscapulohumeral muscular dystrophy
• cancer
• mixed neuronal-glial tumor