LECT2
Description
The LECT2 (leukocyte cell derived chemotaxin 2) is a protein-coding gene located on chromosome 5.
LECT2, originally identified in 1996 as a chemotactic factor for neutrophils, is a hepatokine produced by liver hepatocytes. It functions as a signaling protein, influencing the behavior of other cells. LECT2 is found in various tissues and species, and its levels often fluctuate in response to diseases. Its evolutionary conservation suggests a crucial role, but further investigation is needed to fully understand its involvement in diseases. However, its role in amyloidosis is well-established.
LECT2 is also known as chm-II, chm2.
Associated Diseases
- inherited lipid metabolism disorder
- type 2 diabetes mellitus
- breast angiosarcoma
- common variable immunodeficiency
- cancer
- immunodeficiency 18
- severe combined immunodeficiency due to CARD11 deficiency
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- severe combined immunodeficiency due to CTPS1 deficiency
- Duane retraction syndrome
- immunodeficiency, common variable, 4
- cryohydrocytosis
