LECT2

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Description

The LECT2 (leukocyte cell derived chemotaxin 2) is a protein-coding gene located on chromosome 5.

LECT2, originally identified in 1996 as a chemotactic factor for neutrophils, is a hepatokine produced by liver hepatocytes. It functions as a signaling protein, influencing the behavior of other cells. LECT2 is found in various tissues and species, and its levels often fluctuate in response to diseases. Its evolutionary conservation suggests a crucial role, but further investigation is needed to fully understand its involvement in diseases. However, its role in amyloidosis is well-established.

LECT2 is also known as chm-II, chm2.

Associated Diseases

• inherited lipid metabolism disorder
• type 2 diabetes mellitus
• breast angiosarcoma
• common variable immunodeficiency
• cancer
• immunodeficiency 18
• severe combined immunodeficiency due to CARD11 deficiency
• T-B+ severe combined immunodeficiency due to JAK3 deficiency
• severe combined immunodeficiency due to CTPS1 deficiency
• Duane retraction syndrome
• immunodeficiency, common variable, 4
• cryohydrocytosis