LDLRAD2

LDL-RAD2: A Crucial Gene in Cardiovascular Health

Description

LDL-RAD2, also known as Low Density Lipoprotein Receptor Related Protein 2, is a gene that plays a vital role in regulating cholesterol levels in the body. It is involved in the uptake and metabolism of low-density lipoprotein (LDL), known as the "bad cholesterol." LDL-RAD2 is primarily expressed in the liver and adrenal glands.

Associated Diseases

Mutations in the LDL-RAD2 gene have been linked to several inherited disorders, including:

• Familial hypercholesterolemia (FH): A condition characterized by very high levels of LDL cholesterol, which can lead to early onset of heart disease and strokes.
• Sitosterolemia: A rare condition where the body cannot metabolize certain plant sterols, resulting in elevated cholesterol levels.
• Lipoprotein glomerulopathy: A kidney disease caused by the accumulation of excessive lipids in the kidneys.

Did you Know ?

Studies have shown that individuals with mutations in the LDL-RAD2 gene have an approximately 10-fold increased risk of developing FH compared to the general population.