LCP1
Description
The LCP1 (lymphocyte cytosolic protein 1) is a protein-coding gene located on chromosome 13.
The LCP1 gene encodes Plastin-2, a protein that belongs to the plastin family, which are actin-binding proteins conserved across eukaryotic evolution. These proteins are found in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) exist. Plastin 1 (fimbrin) is another distinct isoform, primarily expressed in the small intestine. The L isoform, encoded by LCP1, is specifically expressed in hemopoietic cell lineages. The T isoform is found in all other normal cells of solid tissues with replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been observed in various types of malignant human cells originating from non-hemopoietic tissues, suggesting its expression is induced during tumorigenesis in solid tissues.
LCP1 encodes a protein that binds to actin (PubMed:16636079, PubMed:17294403, PubMed:28493397). It is involved in the activation of T-cells in response to costimulation via TCR/CD3 and CD2 or CD28 (PubMed:17294403). Additionally, it regulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403).
LCP1 is also known as CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2.
