LCMT1

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Description

The LCMT1 (leucine carboxyl methyltransferase 1) is a protein-coding gene located on chromosome 16.

LCMT1 is a human gene that encodes an enzyme involved in the methylation of proteins. It is also known as Protein-leucine O-methyltransferase and [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1.

LCMT1 adds a methyl group to the carboxyl group of the last leucine amino acid in the protein phosphatase 2A catalytic subunit. This modification forms an alpha-leucine ester residue.

LCMT1 is also known as CGI-68, LCMT, PPMT1.

Associated Diseases

• Parkinson disease
• multiple sclerosis
• lysosomal storage disease
• Alzheimer disease
• type 2 diabetes mellitus
• hyperinsulinism due to INSR deficiency
• hyperinsulinism due to glucokinase deficiency
• diabetes mellitus, transient neonatal, 2
• type 1 diabetes mellitus
• pancreatic beta cell agenesis with neonatal diabetes mellitus
• exercise-induced hyperinsulinism
• acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome
• short stature due to primary acid-labile subunit deficiency
• islet cell adenomatosis
• hyperinsulinemic hypoglycemia, familial, 4
• hyperinsulinemic hypoglycemia, familial, 1
• hyperinsulinemic hypoglycemia, familial, 2