LCLAT1
Description
The LCLAT1 (lysocardiolipin acyltransferase 1) is a protein-coding gene located on chromosome 2.
LCLAT1, also known as ALCAT1, exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity. It catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling. LCLAT1 recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. It also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT) activity, converting 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Additionally, LCLAT1 possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. LCLAT1 is required for the establishment of the hematopoietic and endothelial lineages.
LCLAT1 is also known as 1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LPLAT6, LYCAT, UNQ1849.
Associated Diseases
- alopecia
- hemoglobin E-beta-thalassemia syndrome
- hemoglobin D disease
- dehydrated hereditary stomatocytosis
- microcytic anemia with liver iron overload
- IRIDA syndrome
