LAX1
Description
The LAX1 (lymphocyte transmembrane adaptor 1) is a protein-coding gene located on chromosome 1.
LAX1 negatively regulates signaling pathways triggered by the T-cell antigen receptor (TCR) in T cells and the B-cell antigen receptor (BCR) in B cells.
LAX1 is also known as LAX.
Associated Diseases
- hyper-IgM syndrome type 3
- isolated agammaglobulinemia
- classic Hodgkin lymphoma
- common variable immunodeficiency
- hyper-IgM syndrome type 2
- hyper-IgM syndrome type 5
- severe combined immunodeficiency due to CARD11 deficiency
- BENTA disease
- short-limb skeletal dysplasia with severe combined immunodeficiency
- reticular dysgenesis
