LARS
Lars: A Rare and Debilitating Genetic Disorder
Description
Lars, also known as lipodystrophy and alopecia with regenerating hair on the scalp, is an extremely rare genetic disorder characterized by the complete or partial absence of body fat and hair. While there are variations in the severity of the condition, individuals with Lars typically exhibit:
- Lipodystrophy: A profound deficiency of body fat, resulting in a lean and emaciated appearance
- Alopecia: Loss of hair on the scalp, eyebrows, eyelashes, and body
In some cases, Lars may also present with:
- Growth retardation
- Facial dysmorphisms, such as a triangular face and a small chin
- Insulin resistance and diabetes
- Hepatomegaly (enlarged liver)
- Splenomegaly (enlarged spleen)
- Delayed puberty
Associated Diseases
Lars has been linked to several other genetic conditions, including:
- Hutchinson-Gilford Progeria Syndrome: A rare and fatal disorder characterized by premature aging
- Werner Syndrome: A condition characterized by accelerated aging and increased susceptibility to cancer
- Bloom Syndrome: A condition that increases the risk of cancer and causes growth delays
Did you Know ?
Lars affects approximately 1 in 1,000,000 individuals worldwide, making it an exceptionally rare condition.
