LANCL2
Description
The LANCL2 (LanC like glutathione S-transferase 2) is a protein-coding gene located on chromosome 7.
LanC-like protein 2 (LANCL2) is a protein encoded by the LANCL2 gene in humans. It is found in the plasma and nuclear membranes of immune, epithelial, and muscle cells. LANCL2 is a potential therapeutic target for chronic inflammatory, metabolic, and immune-mediated diseases like Crohn's disease and diabetes. The natural ligand of LANCL2, abscisic acid (ABA), is a newly identified mammalian hormone involved in glycemic control. LANCL2 has been identified as the mammalian ABA receptor through modeling predictions, direct ABA binding, and the loss of ABA's effects when LANCL2 expression is silenced. Binding of ABA or other ligands to LANCL2 increases intracellular cAMP, activates PKA, and suppresses inflammation in macrophages. In hepatocytes, LANCL2 regulates cell survival by activating Akt through its interaction with mTORC2, leading to GLUT4 translocation and glucose uptake. LANCL2 expression in immune cells, adipose tissue, skeletal muscle, and pancreas, along with the potential to manipulate LANCL2 signaling and GLUT4 translocation with ABA, makes it a promising target for glycemic control. However, while ABA release is observed with increasing glycemia, this mechanism fails in type 2 and gestational diabetes. Plasma ABA concentrations also rise after oral glucose load in healthy individuals.
LANCL2 is also known as GPR69B, TASP.
Associated Diseases
- respiratory tract infectious disorder
- glioblastoma
- X-linked severe congenital neutropenia
- common variable immunodeficiency
- isolated agammaglobulinemia
- combined immunodeficiency with skin granulomas
- severe combined immunodeficiency due to IKK2 deficiency
- autosomal recessive severe congenital neutropenia due to JAGN1 deficiency
- combined immunodeficiency due to moesin deficiency
- immunodeficiency 18
- immunodeficiency 19
- idiopathic CD4 lymphocytopenia
- neutropenia, severe congenital, 1, autosomal dominant
- reticular dysgenesis
- monocytopenia with susceptibility to infections
- neutropenia, severe congenital, 2, autosomal dominant
- neutropenia-monocytopenia-deafness syndrome
- nonimmune chronic idiopathic neutropenia of adults
