LAMP3
Description
The LAMP3 (lysosomal associated membrane protein 3) is a protein-coding gene located on chromosome 3.
LAMP3, also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein), is a member of the LAMP family along with LAMP1 and LAMP2. These proteins make up the glycoconjugate coat present on the inside of the lysosomal membrane. In humans, LAMP3 is almost exclusively found in mature Dendritic cells. While LAMP3 can be observed on the surface of dendritic cells, the protein is mainly found within lysosomes. LAMP3 first appears in the MHC Class II compartment and in cells aids in the identifying and processing of an antigen during an immune response. LAMP3 protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes or alveolar cells. Studies have linked LAMP3 with the inhibition of the viral replication of Influenza A cells. LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes. LAMP3 has been shown to be highly expressed in dendritic cells during cell differentiation and maturation.
LAMP3 plays a role in the unfolded protein response (UPR), contributing to protein degradation and cell survival during proteasomal dysfunction. It also participates in the fusion of lysosomes with autophagosomes, modulating the autophagic process. Additionally, LAMP3 promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. It may also be involved in dendritic cell function and adaptive immunity.
LAMP3 is also known as CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403.
