LAIR2

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Description

The LAIR2 (leukocyte associated immunoglobulin like receptor 2) is a protein-coding gene located on chromosome 19.

LAIR2 is a human protein encoded by the LAIR2 gene. It shares similarities with LAIR1, an inhibitory receptor found on mononuclear leukocytes. The LAIR2 gene is located on chromosome 19, specifically at 19q13.4, within a region known as the leukocyte receptor cluster. This cluster contains 29 genes belonging to the immunoglobulin superfamily, including LAIR1. While its exact role is unclear, LAIR2 is suspected to be secreted and might contribute to the regulation of mucosal tolerance. Two different isoforms of the protein have been identified, encoded by distinct transcript variants of the LAIR2 gene.

The precise function of LAIR2 is currently unknown. However, it is believed to be secreted and may play a role in regulating mucosal tolerance.

LAIR2 is also known as CD306.

Associated Diseases

• common variable immunodeficiency
• neutrophil immunodeficiency syndrome
• Brugada syndrome
• severe combined immunodeficiency due to CARD11 deficiency
• isolated agammaglobulinemia
• immunodeficiency 18
• combined immunodeficiency with skin granulomas
• severe combined immunodeficiency due to CTPS1 deficiency
• familial atrial fibrillation
• severe combined immunodeficiency due to IKK2 deficiency
• immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
• immunodeficiency 105
• immunodeficiency 72 with autoinflammation
• BENTA disease
• immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
• immunodeficiency 62