LACTB
Description
The LACTB (lactamase beta) is a protein-coding gene located on chromosome 15.
LACTB (Serine beta-lactamase-like protein LACTB, mitochondrial) is an enzyme encoded by the LACTB gene in humans. It is a 54 kDa protein with significant sequence similarity to bacterial serine proteases belonging to the penicillin-binding protein and beta-lactamase superfamily. LACTB plays a regulatory role in metabolic pathways. Studies have linked LACTB to obesity and demonstrated its tumor suppressor activity in breast cancer, where it modulates lipid metabolism. The LACTB gene resides on chromosome 15q22.1 and comprises 8 exons. Alternative splicing produces multiple transcript variants, resulting in different protein isoforms. While LACTB shares similarities with the beta-lactamase/penicillin-binding protein family involved in bacterial cell wall metabolism, its N-terminal 97 amino acids are not part of the conserved penicillin-binding protein domain and may be responsible for its targeting to organelles. LACTB exhibits widespread expression in various mammalian tissues, with the highest levels observed in human skeletal muscle.
LACTB is also known as G24, MRPL56.
