L3MBTL3
Description
The L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3) is a protein-coding gene located on chromosome 6.
L3MBTL3 is a negative regulator of Notch target gene expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. L3MBTL3 is involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. L3MBTL3 is required for normal maturation of myeloid progenitor cells.
L3MBTL3 is also known as MBT-1, MBT1.
