KRTAP10-3
Description
The KRTAP10-3 (keratin associated protein 10-3) is a protein-coding gene located on chromosome 21.
KRTAP10-3, a keratin-associated protein, is found in the hair cortex. It plays a crucial role in the structure and strength of hair by forming an interfilamentous matrix around hair keratin intermediate filaments. This matrix is essential for the hair shaft's rigidity and resistance, achieved through extensive disulfide bond cross-linking between KRTAP10-3 and hair keratins, both rich in cysteine residues. KRTAP10-3 belongs to the group of high-sulfur keratins, a category of matrix proteins within the hair cortex.
KRTAP10-3 is also known as KAP10.3, KAP18-3, KAP18.3, KRTAP10.3, KRTAP18-3, KRTAP18.3.
Associated Diseases
- thyroid gland adenocarcinoma
- hearing loss, autosomal recessive
- autosomal recessive hypohidrotic ectodermal dysplasia
