KRTAP10-1
Description
The KRTAP10-1 (keratin associated protein 10-1) is a protein-coding gene located on chromosome 21.
KRTAP10-1 is a key component of the hair cortex, where it forms an interfilamentous matrix that surrounds hair keratin intermediate filaments. This matrix is crucial for the structural integrity of the hair shaft, providing rigidity and resistance. KRTAP10-1 achieves this through extensive disulfide bond formation with cysteine residues present in hair keratins. It belongs to the category of high-sulfur keratin-associated proteins, contributing to the overall strength and resilience of hair.
KRTAP10-1 is also known as KAP10.1, KAP18-1, KAP18.1, KRTAP10.1, KRTAP18-1, KRTAP18.1.
Associated Diseases
- thyroid gland adenocarcinoma
- hearing loss, autosomal recessive
- autosomal recessive hypohidrotic ectodermal dysplasia
