KRT6B : keratin 6B
Description
The KRT6B (keratin 6B) is a protein-coding gene located on chromosome 12.
The KRT6B gene provides instructions for making keratin 6b, a tough protein that forms the framework of certain cells. It is found in nails, hair follicles, the skin on palms and soles, and sebaceous glands. K6b pairs with keratin 17 to form keratin intermediate filaments, which create strong networks that protect tissues from damage. K6b is also involved in wound healing.
KRT6B encodes a type II keratin protein, known as keratin 6b or K6b. It forms a heterodimer with type I keratins, specifically KRT16 and/or KRT17. This heterodimer assembles into intermediate filaments that provide structural support and resilience to skin, nails, and other tissues, particularly in areas prone to friction and physical stress. These filaments are also crucial for wound healing.
KRT6B is also known as CK-6B, CK6B, K6B, KRTL1, PC2, PC4.
