KRT6A : keratin 6A
Description
The KRT6A (keratin 6A) is a protein-coding gene located on chromosome 12.
The KRT6A gene provides instructions for making a protein called keratin 6a or K6a. Keratins are tough, fibrous proteins that form the structural framework of certain cells, especially those in the skin, hair, nails, and similar tissues. Keratin 6a is produced in the nails, the skin on the palms and soles of the feet, and the oral mucosa. It partners with keratin 16 to form keratin intermediate filaments, which provide strength and resilience to these tissues, protecting them from damage. Keratin 6a also plays a role in wound healing.
KRT6A encodes an epidermis-specific type I keratin protein that plays a role in wound healing. It is involved in the activation of follicular keratinocytes after wounding but does not significantly contribute to keratinocyte proliferation or migration. KRT6A regulates epithelial migration by inhibiting the activity of SRC during wound repair.
KRT6A is also known as CK-6C, CK-6E, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3.
