KRT4 : keratin 4
Description
The KRT4 (keratin 4) is a protein-coding gene located on chromosome 12.
The KRT4 gene provides instructions for making a protein called keratin 4. Keratins are a group of tough, fibrous proteins that form the structural framework of epithelial cells, which are cells that line the surfaces and cavities of the body. Keratin 4 is found in the moist lining (mucosae) of the mouth, nose, esophagus, genitals, and anus. Keratin 4 partners with a similar protein, keratin 13 (produced from the KRT13 gene), to form molecules known as intermediate filaments. These filaments assemble into strong networks that provide strength and resilience to the different mucosae. Networks of intermediate filaments protect the mucosae from being damaged by friction or other everyday physical stresses.
KRT4 encodes keratin 4, a type II keratin that forms intermediate filaments. It is part of a heterotetramer structure with keratin 13 (KRT13) which provides structural support and resilience to the moist lining (mucosae) of the mouth, nose, esophagus, genitals, and anus. These filament networks protect the mucosae from damage caused by friction and other physical stresses.
KRT4 is also known as CK-4, CK4, CYK4, K4, WSN1.
