KRT27

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Description

The KRT27 (keratin 27) is a protein-coding gene located on chromosome 17.

KRT27 is a keratin gene belonging to the Type I family of intermediate filament proteins.

KRT27 plays a crucial role in the formation of keratin intermediate filaments within the inner root sheath (IRS) of hair follicles. It is essential for the proper assembly of type I and type II keratin protein complexes, which are crucial for the structural integrity of the IRS.

KRT27 is also known as K25IRS3, KRT25C.

Associated Diseases

• ovarian cancer
• low grade glioma
• uncombable hair syndrome
• ringed hair disease
• pili bifurcati
• wooly hair, autosomal recessive 3
• hypotrichosis simplex
• hypotrichosis 4
• epidermolytic palmoplantar keratoderma
• trichodysplasia-xeroderma syndrome
• pili torti
• Marie Unna hereditary hypotrichosis
• autosomal dominant wooly hair
• pili gemini
• monilethrix
• hair defect with photosensitivity and intellectual disability syndrome