KRT16 : keratin 16

Description

The KRT16 (keratin 16) is a protein-coding gene located on chromosome 17.

The KRT16 gene provides instructions for creating a protein called keratin 16 or K16. Keratins, a family of tough, fibrous proteins, form the structural basis of certain cells, particularly those found in the skin, hair, and nails. Keratin 16 is produced specifically in the nails, the skin on the palms of the hands and soles of the feet, and the oral mucosa that lines the inside of the mouth. It pairs with a similar protein, keratin 6a, to create keratin intermediate filaments, strong, resilient structures that give the skin, nails, and other tissues their strength and durability. These filaments protect these tissues from damage caused by friction and other daily stresses. Keratin 16 also participates in wound healing, alongside other keratins.

KRT16 is a type I keratin found specifically in the epidermis, where it plays a crucial role in skin health. It acts as a regulator of innate immunity, particularly in response to breaches in the skin barrier. This means KRT16 helps control the inflammatory response that occurs when the skin is damaged, contributing to the maintenance of the skin's protective barrier.

KRT16 is also known as CK16, FNEPPK, K16, K1CP, KRT16A, NEPPK, PC1.

Associated Diseases

WES Whole Exome Sequencing