KRT13 : keratin 13
Description
The KRT13 (keratin 13) is a protein-coding gene located on chromosome 17.
The KRT13 gene provides instructions for creating keratin 13, a tough protein that is a key part of the structural framework in epithelial cells. These cells line the surfaces and cavities of the body. Keratin 13 is specifically found in the moist linings (mucosae) of the mouth, nose, esophagus, genitals, and anus. It joins with keratin 4 (from the KRT4 gene) to make intermediate filaments, which form strong networks that give strength and resilience to these mucosae. These networks protect the mucosae from damage caused by friction or other everyday physical pressures.
Keratin 13, a type 1 keratin, plays a role in maintaining the health and structure of the tongue's mucosal cells after birth. It helps the tongue respond to physical pressures, potentially by regulating cell growth and division through the proteins CCNE1 and CCNE2.
KRT13 is also known as CK13, K13, WSN2.
