KLK3

Description

The KLK3 (kallikrein related peptidase 3) is a protein-coding gene located on chromosome 19.

KLK3 (Kallikrein-3), also known as Prostate-specific antigen (PSA), is a glycoprotein enzyme produced by the prostate gland in men and paraurethral glands in women. It is a member of the kallikrein-related peptidase family and plays a crucial role in liquefying semen in the ejaculate, allowing sperm to swim freely. KLK3 is also believed to dissolve cervical mucus, facilitating sperm entry into the uterus. While present in small amounts in the serum of men with healthy prostates, elevated KLK3 levels may indicate prostate cancer, prostatitis, or benign prostatic hyperplasia. Its use in prostate cancer screening is controversial due to the potential for overdiagnosis and overtreatment. The FDA approves annual PSA screening for men 50 and older, but the NHS in the UK does not mandate or advise for PSA testing, leaving the decision to the patient and their doctor.

KLK3 is also known as APS, KLK2A1, PSA, hK3.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing