KLHL9

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Description

The KLHL9 (kelch like family member 9) is a protein-coding gene located on chromosome 9.

KLHL9 acts as a substrate-specific adapter in the BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, crucial for proper mitotic progression and cytokinesis. This complex, specifically BCR(KLHL9-KLHL13), facilitates the ubiquitination of AURKB, regulating its dynamic behavior on mitotic chromosomes. This regulation is critical for ensuring accurate mitotic progression and successful completion of cytokinesis.

KLHL9 is also known as -.

Associated Diseases

• KLHL9-related early-onset distal myopathy