KLHL15
Description
The KLHL15 (kelch like family member 15) is a protein-coding gene located on chromosome X.
KLHL15 is a substrate-specific adapter protein for the CUL3 E3 ubiquitin-protein ligase complex. It acts as a bridge between CUL3 and target proteins, leading to their ubiquitination and subsequent degradation by the proteasome. KLHL15 has been shown to target two important proteins: PPP2R5B, a subunit of protein phosphatase 2A (PP2A), and RBBP8/CtIP, a DNA-end resection factor involved in DNA repair. By promoting the degradation of PPP2R5B, KLHL15 regulates the composition of PP2A complexes. By degrading RBBP8/CtIP, KLHL15 influences the DNA damage response, favoring non-homologous end joining (NHEJ) over homologous recombination (HR).
KLHL15 is also known as HEL-S-305, XLID103.
