KLF15
Description
The KLF15 (KLF transcription factor 15) is a protein-coding gene located on chromosome 3.
KLF15, a member of the Krüppel-like factor family, is encoded by the KLF15 gene in humans. Its expression is regulated by various factors, including glucocorticoid receptor activation, fasting, feeding, insulin signaling, and exercise. KLF15 plays a significant role in metabolic regulation, particularly in the liver and muscle tissue. It promotes fat burning and exercise endurance in muscle. Additionally, KLF15 is associated with insulin resistance and obesity. In mice, KLF15 deficiency prevents efficient fat burning and aerobic exercise, while overexpression leads to insulin resistance and obesity resistance.
KLF15 acts as a transcriptional regulator, binding to the GA element of the CLCNKA promoter. It also binds to the KCNIP2 promoter and regulates the circadian expression of KCNIP2 in the heart. Additionally, KLF15 represses CCN2 expression, playing a role in the control of cardiac fibrosis. It is further involved in regulating cardiac hypertrophy by inhibiting MEF2A and GATA4. KLF15 is also implicated in podocyte differentiation. Furthermore, it inhibits MYOCD activity, acts as a negative regulator of TP53 acetylation, and inhibits NF-kappa-B activation by repressing EP300-dependent RELA acetylation.
KLF15 is also known as KKLF.
