KLC3
Title: KLC3: A Multifaceted Protein with Diverse Roles in Health and Disease
Description
Kinesin light chain 3 (KLC3), also known as microtubule-associated protein 1 light chain 3 (MAP1LC3), is a ubiquitous protein found in eukaryotic cells. It plays crucial roles in fundamental cellular processes, including autophagy, cell division, and signal transduction. KLC3 is intricately linked to various human diseases, making it an important target for biomedical research.
Associated Diseases
Dysregulation of KLC3 has been implicated in a wide range of diseases, including:
- Autophagy-related disorders: KLC3 is essential for autophagy, a process that degrades and recycles cellular components. Impairments in autophagy can lead to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
- Neurological disorders: KLC3 is involved in neuronal development and function. Alterations in KLC3 expression have been associated with epilepsy, schizophrenia, and autism spectrum disorders.
- Cancer: KLC3 is implicated in both tumor suppression and progression. In some cancers, reduced KLC3 levels promote tumor growth, while in others, elevated KLC3 may be associated with increased malignancy.
Did you Know ?
- KLC3 is one of the most highly phosphorylated proteins in human cells, with over 100 potential phosphorylation sites. This extensive post-translational modification allows for dynamic regulation of KLC3's functions and interactions.
