KIR2DL3
Description
The KIR2DL3 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3) is a protein-coding gene located on chromosome 19.
KIR2DL3 (Killer cell immunoglobulin-like receptor 2DL3) is a transmembrane glycoprotein expressed by natural killer (NK) cells and some T cell subsets. It belongs to the KIR gene family, which exhibits polymorphism and homology. NK cells are crucial for innate antiviral immune responses, lysing target cells without prior sensitization and regulating immune responses through chemokine and cytokine secretion. NK cell activation depends on the balance of inhibitory and activating signals from various receptors, including KIRs that primarily recognize class I human leukocyte antigen (HLA) molecules. KIR2DL3 has a long cytoplasmic domain, enabling it to transduce inhibitory signals upon ligand binding through an immunoreceptor tyrosine-based inhibitory motif (ITIM). The KIR genes are located within the 1Mb Leukocyte Receptor Complex (LRC) on chromosome 19q13.4. KIR proteins are classified based on their number of extracellular immunoglobulin (Ig) domains and their cytoplasmic domain length (long or short).
KIR2DL3 is also known as CD158B2, CD158b, GL183, KIR-023GB, KIR-K7b, KIR-K7c, KIR2DL, KIR2DS5, KIRCL23, NKAT, NKAT2, NKAT2A, NKAT2B, p58.
