KIFAP3

Description

The KIFAP3 (kinesin associated protein 3) is a protein-coding gene located on chromosome 1.

KIFAP3 is a protein encoded by the KIFAP3 gene in humans. It acts as a non-motor, accessory subunit, forming heterotrimeric kinesin-2 motor proteins with KIF3A and KIF3B or KIF3C. Initially identified in echinoderms and mice, KAP subunits are essential for kinesin-2 motor function. KIFAP3 interacts with the smg GDS protein, a regulator of small G proteins, through its 9 Armadillo repeats. This interaction is modulated by v-src phosphorylation of KIFAP3, influencing its affinity for smg GDS. KIFAP3 is highly concentrated around the endoplasmic reticulum and is thought to connect HCAP (human chromosome-associated polypeptide) with KIF3A/B, a kinesin superfamily protein in the nucleus, playing a role in chromosome interaction with an ATPase motor protein. It is proposed to act as a clamp, stabilizing the C-terminal half of the otherwise unstable stalk coiled-coil. KIFAP3 has been shown to interact with APC, SMC3, and RAP1GDS1.

KIFAP3 plays a crucial role in chromosome movement and tethering during cell division. It binds to the tail domain of the KIF3A/KIF3B heterodimer, forming a heterotrimeric complex. This interaction might regulate the complex's membrane binding.

KIFAP3 is also known as FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing