KIF5B
Description
The KIF5B (kinesin family member 5B) is a protein-coding gene located on chromosome 10.
KIF5B, or Kinesin family member 5B, is a protein encoded by the KIF5B gene in humans. It belongs to the kinesin family of motor proteins.
KIF5B is a microtubule-dependent motor protein responsible for the proper distribution of mitochondria and lysosomes. It can also trigger the formation of neurite-like membrane extensions in non-neuronal cells, dependent on ZFYVE27. During mitotic entry, KIF5B regulates the positioning of centrosomes and the nucleus. Specifically, in the G2 phase of the cell cycle, KIF5B, in a BICD2-dependent manner, counters the function of dynein and facilitates the separation of nuclei and centrosomes. KIF5B is required for the anterograde transport of MAPK8IP3/JIP3 along axons, which is critical for MAPK8IP3/JIP3's role in axon elongation. Through interactions with PLEKHM2 and ARL8B, KIF5B likely directs lysosomes towards microtubule plus ends. KIF5B plays a part in NK cell-mediated cytotoxicity by driving the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) towards the immune synapse between NK lymphocytes and target cells.
KIF5B is also known as HEL-S-61, KINH, KNS, KNS1, UKHC.
Associated Diseases
- cancer
- medullary thyroid gland carcinoma
- thyroid cancer
- spitz nevus
- acinar lung adenocarcinoma
- ophthalmoplegia
