KIF2C
Description
The KIF2C (kinesin family member 2C) is a protein-coding gene located on chromosome 1.
KIF2C is a human gene encoding a kinesin-like protein that is involved in intracellular transport and cell division. It contains common ATPase site structures and is a microtubule-dependent molecular motor. KIF2C regulates microtubule dynamics, playing a critical role in chromosome segregation during anaphase. It may also be essential for coordinating the separation of sister centromeres.
KIF2C, in complex with KIF18B, is the primary driver of microtubule depolymerization at their plus ends during mitosis. This activity regulates microtubule turnover at the kinetochore, contributing to proper chromosome segregation. KIF2C also plays a role in aligning chromosomes during mitosis (chromosome congression) and facilitating a shift in the attachment between chromosomes and microtubules from a lateral to an end-on configuration.
KIF2C is also known as CT139, KNSL6, MCAK.
Associated Diseases
- ovarian cancer
- cancer
- UV-sensitive syndrome 2
- hypertriglyceridemia 2
- familial glucocorticoid deficiency
- cholesterol-ester transfer protein deficiency
- acroleukopathy, symmetric
- familial progressive hyperpigmentation
- hyperpigmentation with or without hypopigmentation, familial progressive
- Rotor syndrome
