KIF24
Description
The KIF24 (kinesin family member 24) is a protein-coding gene located on chromosome 9.
KIF24 is a protein encoded by the KIF24 gene in humans. It belongs to the kinesin family of motor proteins.
KIF24 acts as a negative regulator of ciliogenesis, preventing the formation of cilia at centrioles in cycling cells. It does this by recruiting CCP110 to the mother centriole, which restricts the nucleation of cilia. KIF24 also mediates the depolymerization of microtubules originating from the centriole, potentially suppressing abnormal cilia formation. Upon activation by NEK2, KIF24 participates in the disassembly of the primary cilium during the G2/M phase of the cell cycle, but it does not disassemble fully formed ciliary axonemes. This suggests that KIF24 might suppress the assembly of nascent cilia and, potentially, the reassembly of cilia in cells that have already disassembled their cilia, ensuring the complete removal of cilia in the later stages of the cell cycle. KIF24 plays a crucial role in recruiting MPHOSPH9, a negative regulator of cilia formation, to the distal end of the mother centriole.
KIF24 is also known as C9orf48, bA571F15.4.
