KIF20B
Description
The KIF20B (kinesin family member 20B) is a protein-coding gene located on chromosome 10.
KIF20B (Kinesin family member 20B) is a protein encoded by the KIF20B gene in humans. It has been shown to interact with PIN1.
KIF20B is a plus-end-directed motor enzyme essential for completing cytokinesis, ensuring proper midbody organization and abscission in polarized cortical stem cells. It plays a role in regulating neuronal polarization by transporting specific cargos. KIF20B mobilizes SHTN1 and accumulates PIP3 in the growth cone of primary hippocampal neurons, requiring both tubulin and actin. In the developing telencephalon, it cooperates with SHTN1 to facilitate the transition from a multipolar to a bipolar stage and the radial migration of cortical neurons from the ventricular zone to the neocortex's superficial layer. KIF20B is implicated in cerebral cortex growth and acts as an oncogene, promoting bladder cancer cell proliferation, apoptosis inhibition, and carcinogenic progression.
KIF20B is also known as CT90, KRMP1, MPHOSPH1, MPP-1, MPP1.
