KIF18A
Description
The KIF18A (kinesin family member 18A) is a protein-coding gene located on chromosome 11.
KIF18A is a human protein encoded by the KIF18A gene. It belongs to the kinesin family of motor proteins. KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.
KIF18A is a microtubule-depolymerizing kinesin that plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. It may stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression. This has been demonstrated through various studies (PubMed:17346968, PubMed:18267093, PubMed:18513970, PubMed:19625775).
KIF18A is also known as MS-KIF18A, PPP1R99.
Associated Diseases
- ovarian cancer
- esophageal cancer
- cancer
- male infertility with teratozoospermia due to single gene mutation
- cervical squamous intraepithelial neoplasia
- partial chromosome Y deletion
- female infertility due to oocyte meiotic arrest
- spermatogenic failure 61
