KIAA1279
kiaa1279: Exploring the Gene and Its Implications
Description
Kiaa1279, also known as N-myc downstream-regulated gene 4 (NDRG4), is a gene that plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. It is located on chromosome 11q13.2 and encodes a protein that is involved in multiple signaling pathways.
Associated Diseases
Kiaa1279 has been implicated in a range of diseases, including:
1. Gastrointestinal Cancers: Reduced kiaa1279 expression has been associated with the development of gastric, colorectal, and pancreatic cancers. It has been found to inhibit tumor growth and promote apoptosis in these cancer types.
2. Neuroblastoma: Kiaa1279 has been identified as a tumor suppressor gene in neuroblastoma, a childhood cancer. High levels of kiaa1279 expression are associated with improved patient survival.
3. Lymphoma: Kiaa1279 has been found to play a role in the development and progression of lymphoma, a type of blood cancer. Its expression is often decreased in lymphoma cells, indicating its potential as a therapeutic target.
Did you Know ?
Studies have shown that individuals with low kiaa1279 expression in their tumor cells have a significantly higher risk of developing metastases. Metastasis refers to the spread of cancer from its primary site to other parts of the body. This highlights the importance of kiaa1279 in preventing cancer metastasis.
