KIAA1107
KIAA1107: An Overview
Description:
KIAA1107, also known as TACSTD2, is a protein-coding gene that plays a crucial role in various cellular processes. It is primarily involved in cell adhesion, migration, and signal transduction. The KIAA1107 protein is localized to the cell membrane and interacts with several other proteins to regulate cell-cell interactions and cellular responses.
Associated Diseases:
Mutations in the KIAA1107 gene have been linked to several diseases, including:
- Lung Cancer: KIAA1107 is frequently overexpressed in lung cancer cells, where it promotes cell proliferation, invasion, and metastasis.
- Breast Cancer: Alterations in KIAA1107 expression have been implicated in breast cancer progression and resistance to therapy.
- Ovarian Cancer: KIAA1107 overexpression is associated with poor prognosis and reduced survival rates in ovarian cancer patients.
- Neurological Disorders: Mutations in KIAA1107 have been linked to autism spectrum disorder and intellectual disability.
Did you Know ?
- In patients with non-small cell lung cancer, high levels of KIAA1107 expression are associated with a 52% lower survival rate compared to those with low expression levels.
