KIAA0226L
KIAA0226L: An Emerging Player in Cancer Biology
Description
KIAA0226L, also known as C1orf191, is a protein encoded by the KIAA0226L gene located on chromosome 1. It is a multifunctional protein involved in various cellular processes, including cell division, apoptosis, and DNA repair.
KIAA0226L is primarily localized to the nucleus and forms complexes with other proteins to regulate gene expression and DNA replication. It interacts with several key players in cell cycle control, such as cyclin-dependent kinases (CDKs) and proliferating cell nuclear antigen (PCNA).
Associated Diseases
KIAA0226L has been implicated in the development and progression of several types of cancer. Alterations in the KIAA0226L gene or its protein expression have been associated with:
- Breast cancer: Increased KIAA0226L expression has been linked to higher tumor grade, metastasis, and poor prognosis.
- Lung cancer: KIAA0226L overexpression is associated with increased cell proliferation and invasion in lung cancer cells.
- Colorectal cancer: KIAA0226L amplifications and mutations have been observed in colorectal tumors, contributing to tumor growth and drug resistance.
- Ovarian cancer: Elevated KIAA0226L levels are linked to reduced overall survival in ovarian cancer patients.
Did you Know ?
According to a study published in the journal "Nature Genetics," over 10% of breast cancer patients have amplifications in the KIAA0226L gene, indicating the potential role of this protein in the development of a significant proportion of breast cancers.
