KGFLP2
kgflp2: A Comprehensive Guide
Description
Kgflp2 (Keratinocyte growth factor-like protein 2) is a protein encoded by the KGF2 gene in humans. It belongs to a family of growth factors known as fibroblast growth factors (FGFs) and plays a crucial role in various biological processes, including cell growth, differentiation, and tissue repair.
Kgflp2 is primarily expressed in epithelial cells, which line the surfaces of organs and tissues. It acts as a ligand for the FGFR2 (fibroblast growth factor receptor 2) and FGFR3 receptors. Upon binding to these receptors, Kgflp2 triggers intracellular signaling pathways that regulate cell proliferation, migration, and survival.
Associated Diseases
Mutations or dysregulation of Kgflp2 have been linked to several diseases, including:
- Cancer: Kgflp2 overexpression has been observed in various types of cancer, including lung, breast, and colon cancer. It promotes tumor growth, invasion, and metastasis by enhancing cell proliferation and angiogenesis.
- Skin disorders: Kgflp2 is involved in the regulation of epidermal homeostasis. Its deficiency or mutations can lead to skin disorders such as epidermolytic palmoplantar keratoderma (EPPK) and ichthyosis vulgaris.
- Corneal disorders: Kgflp2 plays a role in corneal development and maintenance. Abnormalities in Kgflp2 expression can cause corneal dystrophies, which are characterized by the accumulation of abnormal proteins in the cornea.
Did you Know ?
Approximately 1 in 50,000 people worldwide are affected by EPPK, a rare skin disorder caused by mutations in the KGF2 gene.
