KGFLP1
kgflp1
Description
KGFLP1 (Keratinocyte Growth Factor-Like Protein 1) is a protein encoded by the KLK7 gene. It is a member of the kallikrein family of serine proteases and is expressed in the skin, hair follicles, and nails.
KGFLP1 is involved in a number of processes related to skin development and homeostasis, including:
- Cell proliferation and differentiation
- Hair follicle growth
- Nail growth
- Sebum production
- Wound healing
Associated Diseases
Mutations in the KLK7 gene have been linked to a number of skin diseases, including:
- Epidermolysis bullosa simplex (EBS): A group of genetic skin disorders that cause blistering and peeling of the skin.
- Pachyonychia congenita (PC): A rare genetic disorder characterized by thickened nails, palms, and soles.
- Nail-patella syndrome (NPS): A rare genetic disorder that affects the development of the nails, kneecaps, and other parts of the body.
Did you Know ?
Mutations in the KLK7 gene are estimated to cause approximately 1% of cases of EBS.
