KEAP1
Description
The KEAP1 gene encodes a protein that plays a crucial role in regulating the cellular response to oxidative stress. KEAP1 interacts with NRF2, a transcription factor that activates the expression of antioxidant and detoxification genes. Under normal conditions, KEAP1 acts as a repressor of NRF2, keeping its activity in check. However, when cells are exposed to oxidative stress, KEAP1 is modified, leading to NRF2 activation and the induction of protective genes. This intricate interplay between KEAP1 and NRF2 is essential for maintaining cellular homeostasis and preventing damage from reactive oxygen species.
Associated Diseases
- Cancer (e.g., lung, liver, prostate, bladder)
- Neurodegenerative diseases (e.g., Parkinson‘s disease, Alzheimer‘s disease)
- Cardiovascular diseases
- Inflammatory diseases
Did you know?
Mutations in the KEAP1 gene are associated with an increased risk of certain cancers, suggesting that KEAP1 plays a critical role in preventing tumor formation.
