KDR

Description:

Kidney Disease Resistance (KDR) is a rare X-linked recessive genetic disorder characterized by progressive scarring and loss of function in the kidneys. It is caused by mutations in the KDR gene, which codes for a protein called vascular endothelial growth factor receptor 2 (VEGFR2). VEGFR2 plays a crucial role in the formation and maintenance of blood vessels in the kidneys and other organs.

Associated Diseases:

KDR is associated with multiple kidney diseases, including:

• Alport syndrome: A condition characterized by progressive kidney disease, hearing loss, and eye abnormalities.
• Focal segmental glomerulosclerosis (FSGS): A condition where scarring occurs in specific areas of the kidney filters.
• Hypertension: High blood pressure.
• Nephrotic syndrome: A condition characterized by heavy protein loss in the urine.

Did you Know ?

Approximately 1 in 100,000 males are affected by KDR.