KCTD19
Description
The KCTD19 (potassium channel tetramerization domain containing 19) is a protein-coding gene located on chromosome 16.
KCTD19 is a transcription regulator that plays a crucial role in male fertility. It is essential for the completion of meiotic prophase in spermatocytes, specifically regulating the progression of the pachytene stage. It promotes the transcriptional activation activity of ZNF541, a zinc finger protein. Moreover, KCTD19 is required for the proper organization of chromosomes during metaphase I.
KCTD19 is also known as -.
Associated Diseases
- partial chromosome Y deletion
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 61
- spermatogenic failure 74
- spermatogenic failure 73
- spermatogenic failure 48
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure, X-linked, 2
- spermatogenic failure 31
- spermatogenic failure 26
- spermatogenic failure 20
