KCNT1 : potassium sodium-activated channel subfamily T member 1

Description

The KCNT1 (potassium sodium-activated channel subfamily T member 1) is a protein-coding gene located on chromosome 9.

The KCNT1 gene provides instructions for making potassium channels, which are crucial for transmitting electrical signals in cells. These channels transport potassium ions in and out of cells, with KCNT1 specifically transporting potassium ions out of neurons in the brain. This flow of ions is essential for activating neurons and sending signals. KCNT1 channels are formed by four alpha subunits, which can be solely from the KCNT1 gene or in combination with alpha subunits from the KCNT2 gene. A molecule called PKC can enhance the currents generated by KCNT1 channels, making them stronger.

KCNT1 is also known as DEE14, EIEE14, ENFL5, KCa4.1, SLACK, Slo2.2, bA100C15.2.

Associated Diseases

• Malignant migrating focal seizures of infancy
• Autosomal dominant nocturnal frontal lobe epilepsy
• Epilepsy, nocturnal frontal lobe, 5
• Developmental and epileptic encephalopathy 14
• Malignant migrating partial seizures of infancy