KCNN2
Description
The KCNN2 (potassium calcium-activated channel subfamily N member 2) is a protein-coding gene located on chromosome 5.
The KCNN2 gene, also known as KCa2.2, encodes for a protein that plays a role in regulating neuronal excitability. This protein forms a voltage-independent calcium-activated potassium channel, contributing to the slow component of synaptic afterhyperpolarization. It interacts with other calmodulin-binding subunits and is crucial for the delayed hyperpolarization that follows action potentials in neurons. KCNN2 has been shown to influence anxiety levels and stress response, with its overexpression in the basolateral amygdala reducing anxiety and corticosterone secretion. Two transcript variants encoding different isoforms have been found for the KCNN2 gene.
The KCNN2 gene encodes a protein that forms a voltage-independent potassium channel activated by intracellular calcium. This activation leads to membrane hyperpolarization, contributing to the slow component of synaptic afterhyperpolarization and regulating neuronal excitability. {ECO:0000269|PubMed:10991935, ECO:0000269|PubMed:32212350, ECO:0000269|PubMed:9287325}
KCNN2 is also known as DYT34, KCa2.2, NEDMAB, SK2, SKCA2, SKCa 2, hSK2.
Associated Diseases
- Dystonia 34, myoclonic
- Neurodevelopmental disorder with or without variable movement or behavioral abnormalities
