KCNK6
Description
The KCNK6 (potassium two pore domain channel subfamily K member 6) is a protein-coding gene located on chromosome 19.
The human KCNK6 gene encodes the K2P6.1 protein, a member of the potassium channel superfamily with two pore-forming P domains. K2P6.1 is considered an open rectifier and is widely expressed. It is stimulated by arachidonic acid and inhibited by internal acidification and volatile anesthetics.
The KCNK6 gene encodes a protein that exhibits outward rectification in a physiological potassium gradient and mild inward rectification in symmetrical potassium conditions.
KCNK6 is also known as K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2.
Associated Diseases
- thyroid gland adenocarcinoma
- essential hypertension, genetic
- supravalvular aortic stenosis
- metabolic syndrome X
- familial hyperaldosteronism
- familial idiopathic steroid-resistant nephrotic syndrome
- Moyamoya disease with early-onset achalasia
- familial atrial fibrillation
- coronary artery disease, autosomal dominant 2
- pulmonary hypertension, primary, 1
- Liddle syndrome 2
