KCNIP3
Description
The KCNIP3 (potassium voltage-gated channel interacting protein 3) is a protein-coding gene located on chromosome 2.
Calsenilin is a protein encoded by the human KCNIP3 gene. It belongs to the neuronal calcium sensor family and interacts with voltage-gated potassium (Kv) channels, particularly Kv4 channels. Calsenilin regulates neuronal excitability by modulating A-type currents in response to calcium changes. It acts as a calcium-regulated transcriptional repressor, interacting with presenilins and repressing A20 expression, influencing anti-inflammatory signaling. Calsenilin interacts with PSEN1 and PSEN2.
Calsenilin, also known as KCNIP3, is a calcium-dependent transcriptional repressor that binds to the DRE element of genes such as PDYN and FOS. Its DNA affinity decreases upon calcium binding but increases with magnesium binding. It may also play a role in nociception.
KCNIP3 is also known as CSEN, DREAM, KCHIP3.
Associated Diseases
- Parkinson disease
- Huntington disease
- cancer
- Gollop-Wolfgang complex
- tibial hemimelia
- tibia, hypoplasia or aplasia of, with polydactyly
- fibular aplasia-ectrodactyly syndrome
- Blount disease
- metaphyseal anadysplasia
- acromesomelic dysplasia 2B
- brachydactyly-preaxial hallux varus syndrome
- acheiropody
- syndactyly type 4
- laurin-Sandrow syndrome
- acromesomelic dysplasia 2C, Hunter-Thompson type
