KCNG1
Description
The KCNG1 (potassium voltage-gated channel modifier subfamily G member 1) is a protein-coding gene located on chromosome 20.
KCNG1 is a human gene that encodes a protein involved in potassium channel function. It belongs to the voltage-gated potassium (Kv) channel family, which plays crucial roles in various physiological processes like neurotransmitter release, heart rate regulation, insulin secretion, and muscle function. KCNG1 is highly expressed in skeletal muscle and exists in multiple isoforms due to alternative splicing. Although KCNG1 cannot form functional channels by itself, it can create functional heterotetrameric channels with KCNB1, influencing the activity of KCNB1's delayed rectifier voltage-gated potassium channel.
KCNG1 is a potassium channel subunit that cannot form functional channels on its own. However, it can form functional heterotetrameric channels in combination with KCNB1. This interaction modulates the activation and deactivation rates of KCNB1's delayed rectifier voltage-gated potassium channel (PubMed:19074135).
KCNG1 is also known as K13, KCNG, KV6.1, kH2.
Associated Diseases
- multiple sclerosis
- transverse myelitis
- bipolar disorder
- Brugada syndrome
- type 2 diabetes mellitus
- spinal cord injury
