KCNE5
Description
The KCNE5 (potassium voltage-gated channel subfamily E regulatory subunit 5) is a protein-coding gene located on chromosome X.
KCNE5, also known as KCNE1-like, is a protein encoded by the KCNE1L gene in humans. It belongs to the KCNE gene family, which comprises five genes, each encoding a type I membrane protein. KCNE subunits are potassium channel regulatory subunits that do not conduct currents themselves but modify the properties of potassium channel pore-forming alpha subunits.
KCNE5, while being the least-studied member of the KCNE family, is known to regulate several Kv channel subtypes. It interacts with KCNQ1, a Kv alpha subunit crucial for ventricular repolarization and various epithelia. This interaction causes a +140 mV shift in the voltage dependence of activation (when co-expressed in CHO cells), potentially inhibiting KCNQ1 activity within the normal physiological voltage range in most tissues. Moreover, KCNE5 inhibits the activity of channels formed with KCNQ1 and KCNE1.
KCNE5 is also known as KCNE1L.
