KCND3
Description
The KCND3 (potassium voltage-gated channel subfamily D member 3) is a protein-coding gene located on chromosome 1.
Potassium voltage-gated channel subfamily D member 3, also known as Kv4.3, is a protein encoded by the KCND3 gene in humans. It plays a crucial role in the cardiac transient outward potassium current (Ito1), a key contributor to the repolarizing phase 1 of the cardiac action potential. Kv4.3 belongs to the potassium channel, voltage-gated, shal-related subfamily, responsible for forming voltage-activated A-type potassium ion channels involved in the repolarization phase of the action potential. The gene has two isoforms of different sizes due to alternative splicing. Gain of function in Kv4.3 is linked to Brugada syndrome, although this is primarily observed through mutations in the beta subunit KCNE3, which indirectly affects Kv4.3 function.
KCND3 encodes the pore-forming alpha subunit of rapidly inactivating A-type potassium channels. It may contribute to the I(To) current in the heart and I(Sa) current in neurons. Its channel properties are modulated by interactions with other alpha subunits and regulatory subunits.
KCND3 is also known as BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22.
