KCND1
Description
The KCND1 (potassium voltage-gated channel subfamily D member 1) is a protein-coding gene located on chromosome X.
KCND1, also known as Kv4.1, is a human gene that encodes a member of the potassium channel, voltage-gated, shal-related subfamily. These channels form voltage-activated A-type potassium ion channels that are important for the repolarization phase of the action potential. KCND1 is expressed in all tissues analyzed, with lower levels in skeletal muscle. Its function is to regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
KCND1 is the pore-forming subunit of rapidly inactivating A-type potassium channels. It may contribute to the I(To) current in the heart and the I(Sa) current in neurons. The channel's properties are modulated by interactions with other alpha subunits and with regulatory subunits.
KCND1 is also known as KV4.1.
